Diagnostic Criteria for Cancer-Associated Cachexia: Insights from a Multicentre Cohort Study.

ABSTRACT:

Background

To explore the association between cachexia, as defined by different diagnostic criteria, and the risk of mortality in individuals with cancer. We also examined which diagnostic criteria are more feasible and appropriate for cancer-associated cachexia in clinical practice.

Methods

A multicentre cohort study was conducted, which involved 5769 participants with cancer. The diagnosis of cachexia was made by applying the initial Fearon criteria (with the appendicular skeletal muscle mass index [ASMI]) and six modified criteria: (1) evaluating the muscle mass through the mid-upper-arm muscle area (MAMA), (2) fat-free mass index (FFMI), (3) calf circumference (CC), (4) hand grip strength (HGS), (5) neutrophil-to-lymphocyte ratio (NLR) and (6) omission of reduced muscle

SUBMITTER: Huo Z 

PROVIDER: S-EPMC11825978 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature