The anticholinergic burden in patients with chronic kidney disease: Patterns, risk factors, and the link with cognitive impairment.

ABSTRACT:

Background

People with chronic kidney disease (CKD) have an elevated risk of cognitive impairment (CI). Medications with anticholinergic activity are recognized for their adverse reactions on central nervous system. The putative association between the anticholinergic burden and CI has not previously been evaluated in patients with CKD. The study aimed to (i) describe prescriptions of medications with anticholinergic activity, (ii) analyze factors associated with these prescriptions, and (iii) evaluate the anticholinergic burden's association with cognitive performance.

Methods

CKD-REIN, a prospective cohort study, enrolled nephrology outpatients with a confirmed diagnosis of CKD (eGFR <60 mL/min/1.73m²). Drug prescriptions were recorded prospectively during the 5

SUBMITTER: Mouheb A 

PROVIDER: S-EPMC11825999 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature