Causal association between serum bilirubin and ischemic stroke: multivariable Mendelian randomization.

ABSTRACT:

Objectives

Previous research has predominantly focused on total bilirubin levels without clearly distinguishing between direct and indirect bilirubin. In this study, the differences between these forms were examined, and their potential causal relationships with ischemic stroke were investigated.

Methods

Two-sample multivariable Mendelian randomization (MVMR) analysis was employed, extracting summary data on bilirubin from the Korean Cancer Prevention Study-II (n=159,844) and the Korean Genome and Epidemiology Study (n=72,299). Data on ischemic stroke were obtained from BioBank Japan (n=201,800). Colocalization analysis was performed, focusing on the UGT1A1, SLCO1B1, and SLCO1B3 genes, which are the primary loci associated with serum bilirubin levels.

Results

Crude 2-

SUBMITTER: Shin JW 

PROVIDER: S-EPMC11826012 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature