Hemichorea-hemiballismus induced by intravenous thrombolytic therapy for acute ischemic stroke: a case report and literature review.

ABSTRACT: Hemichorea-hemiballismus (HCHB) is a rare hyperkinetic movement disorder characterized by unilateral, involuntary, and irregular movements. Although HCHB is the most common poststroke movement disorder, its occurrence as a complication of intravenous thrombolysis is extremely uncommon. While previous studies have demonstrated that intravascular interventions and intravenous thrombolysis can effectively alleviate HCHB symptoms in stroke patients, the pathophysiologic mechanisms underlying HCHB induced by reperfusion therapy remain poorly understood. Herein, we report a case of HCHB induced by intravenous thrombolysis in an acute ischemic stroke patient and explore its possible pathophysiologic underpinnings. Through detailed clinical observations, comprehensive neuroimaging analyses, and an

SUBMITTER: Gao W 

PROVIDER: S-EPMC11826180 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature