Delta/pre-radiomics based on enhanced CT predicts complete response in locally advanced esophageal squamous cell carcinoma.

ABSTRACT:

Objectives

This study aimed to evaluate the effectiveness of neoadjuvant immunochemotherapy (NIC) in patients diagnosed with locally advanced esophageal squamous cell carcinoma (LAESCC), by assessing the performance of models that utilize enhanced computed tomography (CT) images at the pre, post, and delta/pre group stages.

Methods

A total of 225 patients were included in our study and randomly divided into a training set (n = 157) and test set I (n = 68). In addition, we conducted a test set II involving 60 patients from another center. We obtained omics features from CT images before and after NIC. Then, the delta radiomics features were obtained by calculating the differences between the post and pre group features, which was then divided by the pre group features to obta

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11826183 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature