Comprehensive exploration of signal sequence receptor subunit 1 (SSR1) as a diagnostic and prognostic biomarker in liver hepatocellular carcinoma.

ABSTRACT:

Objectives

This study investigated the expression, clinical relevance, and functional role of signal sequence receptor 1 (SSR1) in liver hepatocellular carcinoma (LIHC). SSR1's potential as a diagnostic marker and its impact on tumor progression was assessed through multi-platform data analysis and in vitro functional assays.

Methodology

Expression data from The Cancer Genome Atlas (TCGA), UALCAN, Oncomine, TIMER2.0, and Human Protein Atlas (HPA) were analyzed to assess SSR1 mRNA and protein expression in LIHC. Clinical correlations with tumor stage, race, gender, age, weight, and nodal metastasis were examined using UALCAN. Promoter methylation, mutation frequency, and prognostic significance were evaluated using UALCAN and OncoDB. Gene set enrichment analysis (GSEA) was co

SUBMITTER: Feng B 

PROVIDER: S-EPMC11826213 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature