¹⁸F-fluorodeoxyglucose positron emission tomography-computed tomography for predicting pathological complete response to neoadjuvant chemotherapeutic in breast cancer patients.

ABSTRACT:

Background

Accurately predicting pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) in breast cancer remains a clinical challenge. Current imaging-based models are limited in their ability to integrate key metabolic parameters to enhance prediction accuracy. This study aimed to develop and validate a nomogram using ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) parameters, including maximum standardized uptake value (SUV_max), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), to improve pCR prediction. These parameters, representing both tumor metabolic burden and activity, were hypothesized to collectively provide a robust means of predicting pCR.

Methods

This retrospective coho

SUBMITTER: Ge C 

PROVIDER: S-EPMC11826249 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature