MS4A15 gene expression as a prognostic marker for clinical outcomes in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is the predominant histological subtype of lung cancer. In the past decade, various targeted drugs have prolonged the survival of LUAD patients. Unfortunately, not all LUAD patients can benefit from the current target agents. Although the membrane spanning 4-domains A15 (MS4A15) gene has been implicated in the progression of various cancers, its role in LUAD remains understudied. This study aimed to evaluate the role and potential mechanism of MS4A15 in the progression of LUAD.

Methods

The pan-cancer RNA sequencing and clinical data of LUAD patients, originally comprising data from The Cancer Genome Atlas and Genotypic Tissue Expression, were acquired from University of California Santa Cruz XENA (UCSC XENA). Additionally, the GSE

SUBMITTER: Qiu L 

PROVIDER: S-EPMC11826265 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature