Iron deficiency and infection risk in Danish blood donors.

ABSTRACT:

Background

We aimed to investigate if iron deficiency was associated with infection susceptibility in a large cohort of healthy individuals.

Study design and methods

The Danish Blood Donor Study is a national ongoing prospective study of blood donors. We included 94,628 donors with 338,290 ferritin measurements from March 2010 to October 2022. We performed sex-stratified multivariable Cox regression to estimate the risk of infection for iron-deficient donors compared with iron-replete donors. Infection was defined as either a filled prescription of antibiotics registered in the Danish National Prescription Registry (NPR), or a hospital contact with infection registered in the Danish National Patient Registry (DNPR).

Results

Iron deficiency was associated with an overa

SUBMITTER: Brons N 

PROVIDER: S-EPMC11826298 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature