Intraoperative Esketamine and Postpartum Depression Among Women With Cesarean Delivery: A Randomized Clinical Trial.

ABSTRACT:

Importance

Esketamine has been found to reduce the incidence of postpartum depression (PPD) in randomized clinical trials. However, current evidence from randomized clinical trials does not reflect esketamine's efficacy in clinical settings.

Objective

To assess the clinical efficacy of intraoperative esketamine administration for preventing PPD among women who underwent cesarean delivery.

Design, setting, and participants

This randomized clinical trial was conducted at The First Affiliated Hospital of Chongqing Medical University in Chongqing, China, from March 2023 to February 2024. Pregnant patients admitted for cesarean delivery were included, while those with intellectual dysfunction or contraindications to esketamine were excluded. All participants were assigned

SUBMITTER: Ren L 

PROVIDER: S-EPMC11826358 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature