Clinical performance of the fully automated Lumipulse plasma p-tau217 assay in mild cognitive impairment and mild dementia.

ABSTRACT:

Introduction

Plasma phosphorylated tau (p-tau)217 is a leading blood-biomarker for the detection of amyloid beta (Aβ) pathology. We assessed the performance of a fully automated plasma p-tau217 immunoassay to detect Aβ pathology in mild cognitive impairment (MCI)/mild dementia.

Methods

Paired plasma and cerebrospinal fluid (CSF) samples were obtained at time of diagnostic lumbar puncture (LP) in a specialist memory service. Plasma p-tau217 was measured using the Lumipulse immunoassay platform and ability to detect CSF-defined Aβ positivity assessed.

Results

Of 148 participants (69.4 ± 6.5 years; 54.1% female), 101 had MCI and 47 mild dementia. Median plasma p-tau217 was > 4-fold higher in Aβ+ vs Aβ- individuals with an area under the curve of 0.92 (0.87-0.97). Applica

SUBMITTER: Dyer AH 

PROVIDER: S-EPMC11826441 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature