Physicochemical Design of Nanoparticles to Interface with and Degrade Neutrophil Extracellular Traps.

ABSTRACT: Neutrophil extracellular traps (NETs) are networks of decondensed chromatin, histones, and antimicrobial proteins released by neutrophils in response to an infection. NET overproduction can cause an exacerbated hyperinflammatory response in a variety of diseases and can lead to host tissue damage without clearance of infection. Nanoparticle drug delivery is a promising avenue for creating materials that can both target NETs and deliver sustained amounts of NET-degrading drugs to alleviate hyperinflammation. Here, we study how particle physicochemical properties can influence NET interaction and leverage our findings to create NET-interfacing and NET-degrading particles. We fabricated a panel of particles of varying sizes (200 to 1000 nm) and charges (positive, neutral, negative) and found

SUBMITTER: Raghavan P 

PROVIDER: S-EPMC11826501 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature