Attachment of Hydrogel Patches to Eye Tissue through Gel Transfer using Flexible Foils.

ABSTRACT: Glaucoma, a leading cause of blindness, demands innovative and effective treatments that surpass the limitations of current drug and surgical interventions to lower intraocular pressure. This study describes the generation of cell-repellent hydrogel patches, their deposition on the ocular surface, and a photoinduced chemical binding between the patches and the collagens of the eye. The hydrophilic and protein-repellent hydrogel patch is composed of a copolymer made from dimethylacrylamide and a comonomer unit with anthraquinone moieties. A thin layer of the prepolymer is deposited on a flexible foil. This foil has a hydrophobic side on top and superhydrophilic sides on the bottom. A small amount of added water can penetrate easily through the foil and release the polymer, which is thus tra

SUBMITTER: Tiwari S 

PROVIDER: S-EPMC11826510 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature