Hyaluronic Acid-Coated SPIONs with Attached Folic Acid as Potential T2 MRI Contrasts for Anticancer Therapies.

ABSTRACT: Superparamagnetic iron oxide nanoparticles (SPIONs) are known to be good MRI contrasts, but they have a high tendency to aggregate and their biocompatibility is limited. Hyaluronic acid is highly biocompatible, can provide SPION with colloidal stability, and interacts specifically with tumor cells through the CD44 receptor; therefore, it was used as a stabilizing layer. We successfully obtained SPION coated with hyaluronic acid and further functionalized it with folic acid to construct a dual-targeted system. The physicochemical properties of the nanoparticles were investigated using DLS/ELS, AFM, XRD, and ATR-FTIR. Their magnetic characterization was performed by magnetometry, Mössbauer spectroscopy, ¹H NMR T1 and T2 measurements, and MRI. The nanoparticles' biocompatibility wa

SUBMITTER: Kasprzyk M 

PROVIDER: S-EPMC11826879 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature