Increased SLC7A3 Expression Inhibits Tumor Cell Proliferation and Predicts a Favorable Prognosis in Breast Cancer.

ABSTRACT:

Background

Arginine plays significant and contrasting roles in breast cancer growth and survival. However, the factors governing arginine balance remain poorly characterized.

Objective

We aimed to identify the molecule that governs arginine metabolism in breast cancer and to elucidate its significance.

Methods

We analyzed the correlation between the expression of solute carrier family 7 member 3 (SLC7A3), the major arginine transporter, and breast cancer survival in various databases, including GEPIA, UALCAN, Metascape, String, Oncomine, KM-plotter, CBioPortal and PrognoScan databases. Additionally, we validated our findings through bioinformatic analyses and experimental investigations, including colony formation, wound healing, transwell, and mammosphere formation a

SUBMITTER: He L 

PROVIDER: S-EPMC11826905 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature