Epigenetic disruptions in the offspring hypothalamus in response to maternal infection.

ABSTRACT: DNA methylation is an epigenetic modification that can alter gene expression, and the incidence can vary across developmental stages, inflammatory conditions, and sexes. The effects of viral maternal viral infection and sex on the DNA methylation patterns were studied in the hypothalamus of a pig model of immune activation during development. DNA methylation at single-base resolution in regions of high CpG density was measured on 24 individual hypothalamus samples using reduced representation bisulfite sequencing. Differential over- and under-methylated sites were identified and annotated to proximal genes and corresponding biological processes. A total of 120 sites were differentially methylated (FDR-adjusted p-value < 0.05) between maternal infection or sex groups. Among the 66 sites dif

SUBMITTER: Alsegehy S 

PROVIDER: S-EPMC11826927 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature