Purple Sweet Potato Ameliorates High-Fat Diet-Induced Visceral Adiposity by Attenuating Inflammation and Promoting Adipocyte Browning.

ABSTRACT: Accumulation of visceral fat has been reported to increase systemic inflammation. Purple sweet potato (Ipomoea batatas L., PSP), known for its anthocyanin content, potentiates in mitigating oxidative stress. This study aimed to investigate the underlying mechanisms by which PSP influences body fat deposition. Five-week-old male Sprague-Dawley rats (n = 5) were fed a 43% high-fat diet (HFD) for 2 weeks to induce obesity, followed by 19 weeks of HFD supplemented with 5% PSP. PSP significantly improved body weight and reduced visceral fat mass and adipocyte size. In visceral and subcutaneous adipose tissues, PSP significantly downregulated proteins of FAS, ACC1, and PPARγ with inflammatory markers TNF-α, IL-6, and MCP-1. PSP reduced the proteins of inflammasome components, NLRP3

SUBMITTER: Yen CH 

PROVIDER: S-EPMC11826983 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature