Acidity Reversal Enables Site-Specific Ring-Opening Polymerization of Epoxides from Biprotonic Compounds.

ABSTRACT: Polyethers are versatile materials extensively used in advanced as well as everyday applications. The incorporation of primary amine functionality into polyethers is particularly attractive due to its well-established coupling chemistries. However, the inherent nucleophilicity of amine group poses a challenge in the anionic ring-opening polymerization (ROP) of epoxides and requires the use of robust protecting groups that can withstand the harsh conditions of ROP without triggering undesirable side reactions. In this work, we present streamlined synthesis of amino-functionalized polyethers using classic N-carbamate-protected aminoalcohols as initiators for the ROP of epoxides. A Lewis acid-excess two-component organocatalytic system is found to trigger efficient anionic ROP of epoxi

SUBMITTER: Cesarek U 

PROVIDER: S-EPMC11826984 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature