Association between methylmalonic acid and prevalence of depression in US adults: evidence from NHANES 2011-2014.

ABSTRACT: Background: Depression is a prevalent mental disorder with high morbidity and mortality globally. Methylmalonic acid (MMA) is involved in the pathogenesis of numerous diseases. However, it is unclear whether there is an association between MMA and the prevalence of depression.Methods: This study enrolled 7866 US adults from the 2011-2014 survey of the National Health and Nutrition Examination Survey (NHANES). Individuals were categorized into depression group and non-depression group based on Patient's Health Questionnaire-9 (PHQ-9) score. The association between MMA concentrations and prevalence of depression was analysed by multivariate logistic and linear regression, restricted cubic spline regression, and subgroup analysis. Mediation analysis was used to explore the role

SUBMITTER: Li S 

PROVIDER: S-EPMC11827031 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature