Investigating the shared genetic structure between rheumatoid arthritis and stroke.

ABSTRACT:

Background

Rheumatoid arthritis (RA) increases the risk of stroke. However, the relationship between RA and stroke remains unclear. This study aimed to explore the shared genetics architecture (i.e., common genetic basis between different traits, diseases, or phenotypes) of RA and stroke, aiming to improve the intervention and management of patients with RA and stroke.

Methods

Pooled statistics from publicly available genome-wide association studies for RA (8,255 cases and 409,001 controls) and stroke (43,132 cases and 43,132 controls) were used. A genome-wide positive association was conducted to (examine the comprehensive effects of genetic variants on a particular trait, disease, or phenotype at the genome-wide scale). Local genetic correlation studies used linkage disequ

SUBMITTER: Qin Q 

PROVIDER: S-EPMC11827134 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature