Relation between vitamin D deficiency and Pseudomonas aeruginosa colonization in patients with bronchiectasis.

ABSTRACT:

Background

The relationship between vitamin D deficiency and Pseudomonas aeruginosa (P. aeruginosa) colonization in bronchiectasis patients is not well understood.

Methods

This study was conducted at Shanghai Pulmonary Hospital from June 2014 to May 2018. Serum 25-hydroxyvitamin D levels were measured in patients with bronchiectasis, and clinical data including sputum culture results were collected. To investigate the relationship between vitamin D levels and P. aeruginosa colonization, we conducted correlation analysis and logistic regression. Additionally, in vitro experiments with bone marrow-derived macrophages (BMDMs) infected with P. aeruginosa strain PAO1 were performed to further explore the influence of vitamin D on the bacterial infection and inflammatory response.

SUBMITTER: Wen YH 

PROVIDER: S-EPMC11827138 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature