Association between TRMT61B gene polymorphism and Wilms tumor susceptibility in Chinese children.

ABSTRACT:

Background

Wilms tumor is among the most common pediatric malignant tumors. Although m¹A modification influences the structure and function of RNA and participates in tumorigenesis, the relationship between m¹A methyltransferase TRMT61B gene polymorphisms and Wilms tumor susceptibility is unclear.

Methods

We examined the relationship between TRMT61B gene rs4563180 G > C polymorphism (detected by TaqMan probe method) in 414 children with Wilms tumor and 1199 healthy controls. The relationship between the genotype of each sublayer and the risk of Wilms tumor was studied by stratified analysis. The GTEx database was used to analyze the influence of TRMT61B rs4563180 G > C polymorphism on mRNA expression.

Results

The TRMT61B gene polymorphism signifi

SUBMITTER: Huang X 

PROVIDER: S-EPMC11827147 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature