Life course trajectories of maternal cardiovascular disease risk factors by obstetric history: a UK cohort study using electronic health records.

ABSTRACT:

Background

Women who experience adverse pregnancy outcomes (APOs; gestational hypertension, preeclampsia (PE), gestational diabetes (GD), preterm birth (PTB), small or large for gestational age, miscarriage, multiple miscarriages, stillbirth, and offspring with major congenital anomalies) have increased risk of developing cardiovascular disease (CVD). We aimed to compare cardiometabolic health trajectories across the life course between women with and without APOs.

Methods

We studied 187,186 women with a registered pregnancy in the UK Clinical Practice Research Datalink (CPRD) GOLD linked to Hospital Episode Statistics. Fractional polynomial multilevel models were used to compare trajectories of cardiometabolic risk factors (body mass index [BMI], blood pressure [BP], choles

SUBMITTER: Birnie K 

PROVIDER: S-EPMC11827161 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature