Neutralizing and binding antibody dynamics following primary and booster COVID-19 vaccination among healthcare workers.

ABSTRACT:

Background

Vaccine-induced neutralizing antibodies (NAbs) are key for COVID-19 protective-immunity. As the efficacy of SARS-CoV-2 vaccines declines over time and variants of the virus continue to emerge, the need for booster doses of vaccine remains on the agenda. The aim of this study was to assess NAbs dynamics and its correlation with anti-RBD IgG levels during the nine-month follow-up period after primary-CoronaVac vaccination and booster vaccinations to evaluate vaccination strategies.

Methods

This prospective longitudinal observational study followed 226 healthcare workers who received primary (two doses CoronaVac) and booster (CoronaVac or BNT162b2) immunization. Serum samples were collected at four different time points, two after primary vaccination and two after bo

SUBMITTER: Guzel I 

PROVIDER: S-EPMC11827177 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature