Impact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis.

ABSTRACT:

Background

Understanding the key drivers of SARS-CoV-2 transmission is essential for shaping effective public health strategies. However, transmission risk is subject to substantial heterogeneity related to disease severity, age, sex, comorbidities, and vaccination status in different population settings and regions. We aimed to quantify the impact of these factors on secondary attack rates (SARs) of SARS-CoV-2 across diverse population settings and regions, and identify key determinants of transmission to inform targeted interventions for improving global pandemic response.

Methods

To retrieve relevant literature covering the duration of the COVID-19 pandemic, we searched Ovid MEDLINE, Ovid Embase, Web of Science, and the Cochrane COVID-19 Study Register between January 1,

SUBMITTER: Sumsuzzman DM 

PROVIDER: S-EPMC11827239 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature