Exploring the association between exposure to pesticides, polycyclic aromatic hydrocarbons, and phthalates and metabolic syndrome in National Health and Nutrition Examination Survey in the USA, 2007-2012: utilizing a multi-step statistical strategy.

ABSTRACT:

Background

Pesticides, polycyclic aromatic hydrocarbons (PAHs), and phthalates are recognized as potential contributors to metabolic disorders. Nevertheless, the combined effect of simultaneous exposure to these chemicals on the metabolic syndrome (MetS) remains elusive.

Objectives

To explore the impacts of simultaneous exposure to pesticides, PAHs and phthalates and identify critical chemicals on MetS.

Methods

Based on the National Health and Nutrition Examination Survey (NHANES) database from 2007-2012, our study included 4030 non-pregnant individuals aged 20 years or older. We used the weighted linear regression model, variable selection models (including LASSO regression and BMA models), as well as a mixture exposure model (WQS model) to investigate the correlatio

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11827259 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature