HIF1α controls steroidogenesis under acute hypoxic stress.

ABSTRACT:

Background

Hypoxia is a critical physiological and pathological condition known to influence various cellular processes, including steroidogenesis. While previous studies, including our own, have highlighted the regulatory effects of Hypoxia-Inducible Factor 1α (HIF1α) on steroid production, the specific molecular mechanisms remain poorly understood. This study investigates the role of hypoxia and HIF1α in steroid biosynthesis across multiple experimental models during acute exposure to low oxygen levels.

Methods

To assess the extent to which acute hypoxia modulates steroidogenesis, we employed several approaches, including the Y1 adrenocortical cell line, and a conditional HIF1α-deficient mouse line in the adrenal cortex. We focused on various regulatory patterns that may c

SUBMITTER: Ariyeloye S 

PROVIDER: S-EPMC11827267 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature