Asymmetric U-shaped relationship between blood glucose and white matter lesions: results of a cross-sectional study.

ABSTRACT:

Background

Elderly individuals are susceptible to the accrual of White Matter Lesions (WMLs), a subcategory of cerebral small-vessel disease. WMLs are strongly linked to an increased risk of strokes, intracerebral hemorrhages, and dementia. While the relationship between blood glucose levels and the development of WMLs has been investigated in previous studies, the findings remain inconsistent. Some evidence suggests that glucose dysregulation, including both hypo- and hyperglycemia, may contribute to WML formation through mechanisms such as endothelial dysfunction and chronic inflammation. However, other studies report no significant correlation. This inconsistency underscores the need for further investigation.

Methods

In this investigation, the primary data were derived f

SUBMITTER: Liu D 

PROVIDER: S-EPMC11827292 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature