Prognostic significance of preoperative CT-based sarcopenia in locally advanced rectal cancer: a multicenter retrospective study.

ABSTRACT:

Objectives

The association between preoperative CT-based sarcopenia and prognosis in locally advanced rectal cancer (LARC) remains unclear. The aim of this study was to investigate the relationship between CT-based sarcopenia and clinical outcomes in patients with LARC.

Materials and methods

This multicenter retrospective study analyzed 503 LARC patients who underwent radical resection in three tertiary hospitals in China from January 2018 to June 2021 and were pathologically confirmed. All patients were followed for a period of at least three years. Clinical, pathological, and imaging data were carefully collected. According to the sex-specific skeletal muscle index (SMI), patients were evaluated for the presence of CT-based sarcopenia. The SMI was obtained by measuring the

SUBMITTER: Zhu J 

PROVIDER: S-EPMC11827370 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature