Acupuncture mediates the "gut-testis axis" to improve asthenozoospermia.

ABSTRACT:

Background

Asthenozoospermia is a common cause of male infertility. Studies have shown that sperm quality and motility are affected by the gut-testis axis that can regulate testicular metabolism and function through the gut microbiota and its metabolites. Acupuncture is an important modality of complementary and alternative medicine. It can improve sperm motility, but it remains unclear whether acupuncture can enhance sperm vitality by influencing the gut-testis axis.

Methods

In this study, sperm quality, testicular pathology, and serum hormone levels were assessed using a cyclophosphamide-induced mouse model. Real-time PCR, a western blot analysis, and immunofluorescence techniques were used to assess the effects of acupuncture on the gut barrier and blood-testis barrier fu

SUBMITTER: Hao J 

PROVIDER: S-EPMC11827431 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature