Effect of preoperative dexmedetomidine administration on the bispectral index in children during sevoflurane inhalation anesthesia: a randomized controlled trial.

ABSTRACT:

Background

The available data on the effect of dexmedetomidine premedication on anesthesia depth in children during general anesthesia are limited. This study was designed to determine the effect of preoperative dexmedetomidine administration on the bispectral index (BIS) and sevoflurane requirements in children during sevoflurane anesthesia.

Methods

120 children aged 5 to 12 years undergoing concealed penis repair or hypospadias plastic surgery were randomized to receive preoperative administration of 0.25 µg kg^- 1 dexmedetomidine, 0.5 µg kg^- 1 dexmedetomidine, 0.75 µg kg^- 1 dexmedetomidine, or the same volume of placebo. The primary outcome was the change in the BIS value from before dexmedetomidine administration to 60 min after surgical i

SUBMITTER: Xiang Z 

PROVIDER: S-EPMC11827466 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature