Network pharmacology and experimental verification in vivo reveal the mechanism of Zhushao Granules against ulcerative colitis.

ABSTRACT:

Background

Zhushao Granules (ZSG) had exhibited beneficial effects in the treatment of ulcerative colitis (UC) as an effective herbal prescription in Traditional Chinese Medicine. However, the underlying anti-inflammatory mechanism of ZSG remains unclear. This study aimed to decipher the mechanism of ZSG against UC combining network pharmacology and animal-based experiments.

Methods

Network pharmacology was employed to identify active components and therapeutic targets of ZSG against UC. The protein-protein interaction (PPI) network was constructed among the therapeutic targets using the STRING database, and GO and pathway analyses were carried out using DAVID. Then, the "herb-component-target-pathway" network based on therapeutic targets was established and the topological

SUBMITTER: Gong B 

PROVIDER: S-EPMC11827476 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature