Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach.

ABSTRACT:

Purpose

Neovascular eye diseases, such as proliferative diabetic retinopathy (PDR), wet age-related macular degeneration (wAMD) and retinopathy of prematurity (ROP), are major causes of vision loss and blindness worldwide. Our transcription factor motif enrichment analysis highlighted RUNX1 as a key regulator in the hypoxic response. The purpose of this study was to characterize how loss of Runx1 affects physiological and pathological retinal vasculature formation.

Methods

RNA-seq analysis and Transcription factor motif enrichment analysis were conducted in hypoxic and normoxic HUVECs. Conditional deletion of Runx1 in endothelial cells In mice was achieved using recombinase driver Cdh5-CreERT2. Vascular coverage, density, vessel progression, branchpoints, and sprout numbers

SUBMITTER: Ding X 

PROVIDER: S-EPMC11827618 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature