Benzodiazepine rescue medication administration for seizure clusters: Real-world retrospective outcomes.

ABSTRACT:

Objective

Benzodiazepine rescue medications are established as therapy for acute termination of seizure clusters. A post-hoc analysis of a clinical trial of seizure cluster treatment with diazepam nasal spray found a potential longer-term impact over a year of treatment. In this retrospective analysis, we tested the hypothesis that benzodiazepine-treated seizure clusters are associated with prolonged time to the next seizure cluster compared with untreated seizure clusters in a patient-reported real-world database.

Methods

We analyzed data on self-reported seizures and benzodiazepine rescue medication administration in the Seizure Tracker™ database between 2007 and 2022. Kaplan-Meier analysis was used to compare treated vs untreated seizure clusters with respect to time to s

SUBMITTER: Chiang S 

PROVIDER: S-EPMC11827719 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature