Effect of in utero exposure to antiepileptic drugs on cortical networks and neurophysiological outcomes at 6 years.

ABSTRACT:

Objective

The human brain undergoes an activity-dependent organization during late gestation, making it very sensitive to all effects on the spontaneous neuronal activity. Pregnant mothers with epilepsy are treated with antiepileptic drugs (AEDs) that may reach the fetus and cause altered cortical network activity after birth. However, it is not known whether these functional effects of intrauterine AED exposure persist later in childhood.

Methods

We studied cortical activity networks computed from electroencephalographic recordings during sleep of 25, 6-year-old children with in utero exposure to AEDs and 21 without exposure. The frequency-specific networks were determined for N1 and N2 sleep states, and the study groups were compared for sleep-state-specific changes and dy

SUBMITTER: Konig S 

PROVIDER: S-EPMC11827741 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature