The AIB1 gene polyglutamine repeat length polymorphism and the risk of breast cancer development.

ABSTRACT:

Purpose

Carriers of BRCA1/2 mutations are at high lifetime risk of breast cancer (BC); however, the BC onset broadly vary in individual patients. Recently, polyglutamine (poly-Q) repeat length polymorphism of the amplified in breast cancer 1 (AIB1) gene was analyzed as a risk factor influencing BC onset in BRCA1/2 mutation carriers with contradictory results.

Methods

We genotyped AIB1 poly-Q repeat in 243 BRCA1/2 mutation carriers, 61 patients with familial BC (negatively tested for the presence of BRCA1/2 mutation), 221 patients with sporadic BC, and 176 non-cancer controls using denaturing high-performance liquid chromatography and statistically evaluated the effect of AIB1 poly-Q repeat length polymorphism on BC onset.

Results

Having used previously published stati

SUBMITTER: Kleibl Z 

PROVIDER: S-EPMC11827769 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature