Remote Preconditioning Provides Protection Against Retinal Cell Death From Retinal Detachment.

ABSTRACT:

Purpose

Remote preconditioning involves injury to a tissue that results in protection to a subsequent injury in a distal tissue. Here, we investigated the impact of remote preconditioning on retinal detachment (RD) injury, hypothesizing that a previous contralateral RD would protect the fellow retina against inflammation and cell death following its detachment.

Methods

RD was created in adult C57BL/6J mice with subretinal sodium hyaluronate injection. Preconditioning involved RD in the right eye at 1, 3, 7, or 28 days before left eye detachment, whereas the control group only received RD to the left eye. Retinas were harvested 24 hours post-left eye detachment in both groups. Cell death was assessed using Cell Death Detection ELISA and mRNA expression was evaluated via qRT-P

SUBMITTER: Scavuzzi BM 

PROVIDER: S-EPMC11827864 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature