Efficiency of case-crossover versus time-series study designs for extreme heat exposures.

ABSTRACT:

Background

Time-stratified case-crossover (CC) and Poisson time series (TS) are two popular methods for relating acute health outcomes to time-varying ubiquitous environmental exposures. Our aim is to compare the performance of these methods in estimating associations with rare, extreme heat exposures and mortality-an increasingly relevant exposure in our changing climate.

Methods

Daily mortality data were simulated in various scenarios similar to observed Los Angeles County data from 2014 to 2019 (N = 367,712 deaths). We treated observed temperature as either a continuous or dichotomized variable and controlled for day of week and a smooth function of time. Five temperature dichotomization cutoffs between the 80th and 99th percentile were chosen to investigate the effects o

SUBMITTER: Schimke C 

PROVIDER: S-EPMC11828017 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature