Hydrothermal treatment of yeast cell wall generates potent anti-proliferative agents targeting MCF7 breast cancer cells effectively even under culture conditions separated by a plastic wall.

ABSTRACT: Traditionally, the yeast cell wall (YCW) has limited applications because of its low solubility. To overcome this, a novel method was developed using a hydrothermal reaction to enhance its solubility and decrease its viscosity; this resulted in the production of a soluble form of YCW, known as the YCW treated with hydrothermal reaction (YCW-H), with broader chemical composition. However, the biological impact of YCW-H is unclear, excluding its reported plant growth-promotion by effectively regulating soil microspheres. This study investigated the potential of YCW-H to inhibit MCF-7 breast cancer cell proliferation. YCW-H demonstrated significant anti-proliferative effects on MCF7 cells, reducing cell growth by 58.7% ± 6.9 even when physically separated from the cells by a plastic wall. The

SUBMITTER: Kitagawa T 

PROVIDER: S-EPMC11828357 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature