<i>fmo-4</i> promotes longevity and stress resistance via ER to mitochondria calcium regulation in <i>C. elegans</i>.

ABSTRACT: Flavin-containing monooxygenases (FMOs) are a conserved family of xenobiotic enzymes upregulated in multiple longevity interventions, including nematode and mouse models. Previous work supports that C. elegans fmo-2 promotes longevity, stress resistance, and healthspan by rewiring endogenous metabolism. However, there are five C. elegans FMOs and five mammalian FMOs, and it is not known whether promoting longevity and health benefits is a conserved role of this gene family. Here, we report that expression of C. elegans fmo-4 promotes lifespan extension and paraquat stress resistance downstream of both dietary restriction and inhibition of mTOR. We find that overexpression of fmo-4 in just the hypodermis is sufficient for these benefits, and that this expression

SUBMITTER: Tuckowski AM 

PROVIDER: S-EPMC11828484 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature