Proton Pump Inhibitor Use and Incident Cardiovascular Disease in Older Postmenopausal Women.

ABSTRACT:

Background

Epidemiological studies have been inconsistent regarding an association between proton pump inhibitor (PPI) use and risk of primary cardiovascular disease (CVD) events.

Methods

We studied 85,189 postmenopausal women (mean age 63 years at baseline) without known CVD at enrollment into the Women's Health Initiative Observational Study (1993-1998). PPI use was determined from medication inventories at baseline and Year-3. CVD events were physician adjudicated and defined as a composite of coronary heart disease, stroke, and CVD mortality. Follow up was from baseline to September 2010. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for incident CVD according to baseline PPI use (no/yes), use dura

SUBMITTER: Soliman AI 

PROVIDER: S-EPMC11828671 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature