Development and Characterization of Calcium Ion-Enhanced Nanophytosomes Encapsulating Pomegranate Fruit Extract.

ABSTRACT: Nanophytosomes (NP_S) loaded with whole pomegranate fruit extract with peel and arils (PFE) at different levels of phosphatidylcholine (PC) were produced using a thin-film hydration method and reinforced with calcium ions. PFE was obtained by pressing whole pomegranates, followed by mixing with PC at ratios of 1:1, 1:2, and 1:3, which then strengthens the phytosome wall by CaCl₂ solutions (1.35 and 2.70 mM) and lyophilized to create a stable powder form. The characteristics of the NP powders, including encapsulation efficiency (EE), particle size, ζ-potential, polydispersity index (PDI), structure, microstructure, and thermal properties, were evaluated. Additionally, the storage stability of phenolic compounds over two months was investigated. The PFE powder demonstrat

SUBMITTER: Sedighi R 

PROVIDER: S-EPMC11828700 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature