Short- versus standard-course antimicrobial therapy for children with urinary tract infection: A meta-analysis.

ABSTRACT:

Aim

To determine if short- (2-5 days) course antimicrobials are as effective as standard- (6-14 days) course antimicrobials in the treatment of symptomatic UTI in children.

Methods

MEDLINE and EMBASE were searched from their origin to January 2024. We only considered randomised controlled trials in children <18 years of age. The main outcomes of interest were UTI or bacteriuria at the end of therapy.

Results

Nine studies were included. Compared to children treated with a standard course of antimicrobials, those treated with shortened courses of antimicrobials did not have significantly different risks of UTI at the end of therapy (risk difference 2.2%, CI: 0.0-4.3). Risk of bacteriuria at end of therapy (RD = 8.7%, CI: 5.3-12.2) was slightly higher in children treated

SUBMITTER: Mueller GD 

PROVIDER: S-EPMC11828724 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature