Faecal biomarkers in children with coeliac disease: A way forward?

ABSTRACT:

Aim

Novel markers to reflect the intestinal damage in coeliac disease are needed. We studied the potential of faecal and serum neopterin, and faecal myeloperoxidase, human β-defensin-2, and lipocalin-2 in a case-control study.

Methods

Data were collected from medical records and a biobank including newly diagnosed coeliac disease patients, potential coeliac disease patients and non-coeliac controls. Commercially available ELISA assays were used for measuring the biomarkers.

Results

Altogether 19 patients with coeliac disease (median age 9.0 years), 8 with potential coeliac disease (4.0 years) and 18 controls (6.5 years) were included. The highest faecal neopterin levels were seen in potential coeliac disease, followed by controls and coeliac disease (median 513 vs. 37

SUBMITTER: Kivela L 

PROVIDER: S-EPMC11828732 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature