Genetic risk factors for periodontitis: a genome-wide association study using UK Biobank data.

ABSTRACT:

Objectives

Periodontitis is linked with many health conditions, but its genetic basis is not yet understood. This genome-wide association study (GWAS) aimed to investigate the genetic variants associated with periodontitis.

Materials and methods

This study utilised UK Biobank participants of European descent. Individuals were categorised as "having periodontitis" if they self-reported having 'painful gums', 'bleeding gums' or 'loose teeth' (n = 68,482), or as "controls" for those without these symptoms (n = 307,342). We conducted GWAS of this binary periodontitis phenotype using logistic regression models with PLINK2.0 adjusting for age, sex and the first 15 principal components to account for population stratification.

Results

There were 376,611 participants (mean ba

SUBMITTER: Gao C 

PROVIDER: S-EPMC11828758 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature