Therapeutic effect of curcumin derivative GT863 on prion-infected mice.

ABSTRACT: In prion diseases, the cellular prion protein (PrP^C) forms an abnormal, infectious, and disease-causing form known as PrP^Sc. Inhibition of prion propagation is a key approach for the treatment of these diseases. We report on a curcumin-based compound, GT863 (formerly known as PE859) that displays therapeutic efficacy when administered orally. GT863 inhibited abnormal prion protein formation in prion-infected neuroblastoma cells in a prion strain dependent manner: effectively for RML prion and marginally for 22 L prion. Treatment with ad libitum GT863-containing feed prolonged the incubation period of intracerebrally RML prion infected Tga20 mice by 217% increase in mean. Although the 263 K prion-infected Tg7 mice were less sensitive to GT863 than RML prion infected Tg

SUBMITTER: Teruya K 

PROVIDER: S-EPMC11828863 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature