LmCen^-/- based vaccine is protective against canine visceral leishmaniasis following three natural exposures in Tunisia.

ABSTRACT: Dogs are the main reservoir host of Leishmania infantum, etiological agent of zoonotic visceral leishmaniasis (ZVL). An effective vaccine against Canine Visceral Leishmaniasis (CVL) will help the control and elimination of ZVL. In this study, we evaluated in dogs the safety, immunogenicity, and efficacy of a live attenuated Leishmania major Centrin gene-deleted (LmCen^-/-) as a vaccine. Two doses (10⁶ or 10⁷) of LmCen^-/- vaccine were administered intradermally in a prime-boost regimen. Both vaccine doses induced equally high level of IgG anti-Leishmania and exhibited strong antigen-specific cellular responses with IFN-γ production by CD4 + T cells one-month post-immunization. A second cohort of dogs was vaccinated with 10⁶ LmCen^-/-

SUBMITTER: Boussoffara T 

PROVIDER: S-EPMC11828870 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature