The neuronal and glial cell diversity in the celiac ganglion revealed by single-nucleus RNA sequencing.

ABSTRACT: The sympathetic nervous system regulates various visceral functions, including those of the heart, lungs, and digestive system, and maintains homeostasis. The prevertebral ganglia (PVG) in the peripheral nervous system serve as a vital relay station, transmitting efferent signals to visceral organs. The PVG receives innervation from intestinofugal afferent neurones (IFANs) that originate from the enteric plexus, as well as from spinal sensory nerves that innervate the enteric tract. While neural circuits comprising sensory and sympathetic nerves have been proposed, the exact diversity of the individual neurones in these circuits is still not well characterized in rats. In this study, we employed single-nuclei RNA-sequencing to characterize all the cell types present in the celiac ganglion

SUBMITTER: Kanda H 

PROVIDER: S-EPMC11828872 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature