Tongue coating microbial communities vary in children with Henoch-Schonlein purpura.

ABSTRACT: Previous research has shown that microbes play a role in immune-related diseases. Our study reveals that children with Henoch-Schönlein purpura nephritis have distinct and altered tongue coating microbiota, characterized by significant changes in species richness, diversity, and specific microbial compositions compared with healthy controls. Nevertheless, the particular involvement of tongue coating microbiota in Henoch-Schönlein Purpura remains unclear. A total of 26 children were enrolled, including 13 patients with HSP and 13 healthy children. Tongue coating samples were collected for DNA extraction and 16S rRNA gene sequencing. Alpha diversity indices, including ACE, Chao1, Shannon, and Simpson indices, revealed significantly lower richness and diversity of tongue coating microbiota in

SUBMITTER: Pang S 

PROVIDER: S-EPMC11828920 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature