Elimination of apoptotic cells by non-professional embryonic phagocytes can be stimulated or inhibited by external stimuli.

ABSTRACT: Active elimination of apoptotic cells is very important for maintaining homeostasis of early embryos. Recent observations on mouse blastocysts freshly isolated from healthy dams have shown that the majority of incidentally occurring apoptotic cells is eliminated by neighbouring embryonic cells. Some apoptotic cells escape phagocytosis, but the frequency of such processes usually does not exceed 10%. The aim of the current study was to evaluate whether the non-professional embryonic phagocytes can respond to experimentally induced increase in apoptosis by increasing the frequency of efferocytosis and whether their activity can be decreased by selective inhibition of specific component of efferoctosis machinery. Experiments were performed in vitro on cultured mouse blastocysts with a differe

SUBMITTER: Pisko J 

PROVIDER: S-EPMC11828932 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature